产品编号:2957-1
产品描述:Akt1 antibody
反应种属:
实验方法:
标记:
规格:100ul
供应商:Epitomics
价格(RMB):2100.00
订购:
说明书:
Cat.#: 2957-1
Akt1/PKBa is a serine/threonine protein kinase whose kinase activity plays a key role in cellular functions such as apoptosis, glycogen synthesis, and cell growth. Moreover, it plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface (2). It promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Akt1/PKBa is activated by various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and insulin and insulin-like growth factor I (IGF-I) (1, 2). Defects in Akt1 are associated with breast, colorectal, and ovarian cancer (2).
WB
WB: 1:1,000-10,000
Human
A synthetic peptide corresponding to residues in human Akt1 was used as an immunogen.
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
1. Burgering, B.M. and Coffer P.J.. Nature 376(6541): 599– 602, 1995. 2. The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res. D142-D148 (2010). 3. Hajduch, E., et al. FEBS Lett. 492(3): 199–203, 2001. 4. Cross, D.A., et al. Nature 378(6559): 785–789, 1995.
