产品编号:R142-1
产品描述:Recombinant Human sRANKR
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Human Soluble Receptor Activator of NF-KappaB (sRANK)
(TNFRSF11A, CD265, ODFR, OFE, RANK, TRANCER)
Prod. No.: R142
Source E. Coli
Pkg. Size: 1 mg, 100 µg
Description
Background:
RANK (Receptor Activator of Nuclear Factor κ B) is a member of the tumor necrosis factor receptor (TNFR) family, which is involved in the regulation of dendritic cell function.1 RANK is expressed on osteoclasts and their precursors, hematopoietic precursors, dendritic cells, and mammary epithelial precursors2 and is known as a regulator of development and activation of osteoclasts in bone remodeling.3 Activation of the RANK-RANKL signaling pathway is directly responsible for dramatic focal erosions that are observed in inflammatory arthritis and aseptic loosening of orthopaedic implants.4
Source
E. Coli
State of Matter
Purity
>98% by SDS Page and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<1.0 EU/µg
Biological Activity
The biological activity of Human Receptor Activator of NF-KappaB Receptor is determined by its ability to suppress the production of IFN-gamma from human PBMCs.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGPDEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG YHWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFSSTD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK
References
1. Higashio K et al. (1998) Biochem Biophys Res Commun. 253: 395
2. Baron R et al. (2006) J clin Invest. 116: 1525
3. Murali R et al. (2004) J Biol Chem. 279: 8269
4. Looney RJ et al. (2004) J Musculoskelet Neuronal Interact 4: 276
Related Products
Anti-Human sRANK (Antigen Aff. Pur.) (Leinco Prod. No.: R1139)
Anti-Human sRANK-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: R1137)
