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Recombinant Human VE-Cadherin

产品编号:C1362-50

产品描述:Recombinant Human VE-Cadherin

反应种属:

实验方法:

标记:

规格:50ug

供应商:Leinco

价格(RMB):4725.00

订购:订购

说明书:

Recombinant Human Vascular Endothelial-Cadherin (VE-Cadherin)
Purified No Carrier Protein
(Cadherin-5 (CDH5), 7B4, CD144, VE-Cad, VEC)
Prod. No.: C1362
Source NSO Cells
Pkg. Size: 1 mg, 50 µg
Storage: -20°C to -70°C

Description
Background:

Vascular endothelial-cadherin (VE-Cadherin) also known as cadherin-5 is an endothelial specific, homophilic adhesion molecule located at the lateral cell surface.1 VE-Cadherin is crucial for the proper assembly of vascular structures and the maintenance of vascular integrity.2 It plays a pivotal role in the formation, maturation and remodeling of the vascular wall.3 VE-cadherin is a positive and endothelial cell-specific regulator of transforming growth factor-beta (TGF-beta) signaling. Therefore, the reduction or inactivation of VE-cadherin may contribute to progression of diseases where TGF-beta signaling is impaired.4

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human VE-Cadherin is Mr 89 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 116 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

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References
1. Vestweber D et al. (1997) J Cell Sci. 110: 583
2. Lambert O et al. (2008) Biochem Soc Trans. 36: 189
3. Gavard J et al. (2009) FEBS Lett. 583: 1
4. Dejana E et al. (2008) EMBO J. 27: 993
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