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Recombinant Human TrkB

产品编号:T405-100

产品描述:Recombinant Human TrkB

反应种属:

实验方法:

标记:

规格:100ug

供应商:Leinco

价格(RMB):5100.00

订购:订购

说明书:

Recombinant Human Tropomyosin-Related Kinase B (TrkB)
Purified No Carrier Protein
(NTRK2, GP145-TrkB)
Prod. No.: T405
Source NSO Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C

Description
Background:

Tropomyosin-related kinase B (TrkB) is a receptor for neurotrophins, a family of closely related proteins that are important physiological regulators of the survival of specific neurons within the peripheral nervous system (PNS) of vertebrates.1 TrkB is an independent prognostic marker in patients with gastric cancer and appears to be associated with metastatic potential.2 Trk-B pathway down-regulation may be the major pathogenesis for Major depressive disorder (MDD).3

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human TrkB is Mr 71.7 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 120-130 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>90% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

cptsckcsa sriwcsdpsp givafprlep nsvdpenite ifianqkrle iineddveay vglrnltivd sglkfvahka flknsnlqhi nftrnkltsl srkhfrhldl selilvgnpf tcscdimwik tlqeaksspd tqdlyclnes skniplanlq ipncglpsan laapnltvee gksitlscsv agdpvpnmyw dvgnlvskhm netshtqgsl ritnissdds gkqiscvaen lvgedqdsvn ltvhfaptit flesptsdhh wcipftvkgn pkpalqwfyn gailneskyi ctkihvtnht eyhgclqldn pthmnngdyt liakneygkd ekqisahfmg wpgiddganp nypdviyedy gtaandigdt tnrsneipst dvtdktgreh diegrmdpks cdkthtcppc papellggps vflfppkpkd tlmisrtpev tcvvvdvshe dpevkfnwyv dgvevhnakt kpreeqynst yrvvsvltvl hqdwlngkey kckvsnkalp apiektiska kgqprepqvy tlppsrdelt knqvsltclv kgfypsdiav ewesngqpen nykttppvld sdgsfflysk ltvdksrwqq gnvfscsvmh ealhnhytqk slslspgkhh hhhh

References
1. Klein R et al. (1996) Genes Dev. 10: 2849
2. Wiley-Liss et al. (2009) J Surg Oncol.
3. Tsai SJ et al. (2004) Med Hypotheses 62: 215
Related Products
Anti-Human TrkB (Antigen Aff. Pur.) (Leinco Prod. No.: T423)
Anti-Human TrkB-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: T488)