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Recombinant Human Tie-1

产品编号:T401-1

产品描述:Recombinant Human Tie-1

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:订购

说明书:

Recombinant Human Tyrosine Kinase With Immunoglobulin-Like and EGF-Like Domains-1 (Tie-1)
Purified No Carrier Protein
(JTK14, TIE)
Prod. No.: T401
Source NSO Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C

Description
Background:

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (Tie-1) are novel endothelial cell tyrosine kinase receptors that are essential for vascular development and remodeling in the embryo.1 They are expressed almost exclusively in endothelial cells.2Tie-1 also have a role in the regulatory pathways of early hematopoiesis and angiogenesis.3 It is upregulated in diseases such as atherosclerosis and rheumatoid arthritis.4

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human Tie-1 is Mr 107 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 130-140 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from a sterile solution containing 20 mM Tris, 0.5 M NaCl and 10% Sucrose.
Purity
>90% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

avdltllan lrltdpqrff ltcvsgeaga grgsdawgpp lllekddriv rtppgpplrl arngshqvtl rgfskpsdlv gvfscvggag arrtrviyvh nspgahllpd kvthtvnkgd tavlsarvhk ekqtdviwks ngsyfytldw heaqdgrfll qlpnvqppss giysatylea splgsaffrl ivrgcgagrw gpgctkecpg clhggvchdh dgecvcppgf tgtrceqacr egrfgqscqe qcpgisgcrg ltfclpdpyg cscgsgwrgs qcqeacapgh fgadcrlqcq cqnggtcdrf sgcvcpsgwh gvhceksdri pqilnmasel efnletmpri ncaaagnpfp vrgsielrkp dgtvllstka ivepekttae fevprlvlad sgfwecrvst sggqdsrrfk vnvkvppvpl aaprlltkqs rqlvvsplvs fsgdgpistv rlhyrpqdst mdwstivvdp senvtlmnlr pktgysvrvq lsrpgeggeg awgpptlmtt dcpepllqpw legwhvegtd rlrvswslpl vpgplvgdgf llrlwdgtrg qerrenvssp qartalltgl tpgthyqldv qlyhctllgp asppahvllp psgppaprhl haqalsdsei qltwkhpeal pgpiskyvve vqvaggagdp lwidvdrpee tstiirglna strylfrmra siqglgdwsn tveestlgng lqaegpvqes raaeegldqq diegrmdpks cdkthtcppc papellggps vflfppkpkd tlmisrtpev tcvvvdvshe dpevkfnwyv dgvevhnakt kpreeqynst yrvvsvltvl hqdwlngkey kckvsnkalp apiektiska kgqprepqvy tlppsrdelt knqvsltclv kgfypsdiav ewesngqpen nykttppvld sdgsfflysk ltvdksrwqq gnvfscsvmh ealhnhytqk slslspgkhh hhhh

References
1. Vartikovski L et al. (1999) J Vasc Res. 36: 272
2. Peters KG et al. (2002) Mol Cell Biol. 22: 1704
3. Albita M et al. (2002) Cancer 94: 1517
4. Sukhatme VP et al. (2009) FEBS Lett.
Related Products
Anti-Human Tie-1 (Leinco Prod. No.: T447)
Anti-Human Tie-1 (Antigen Aff. Pur.) (Leinco Prod. No.: T469)
Anti-Human Tie-1-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: T500)