产品编号:T403-100
产品描述:Recombinant Human TRAIL R4
反应种属:
实验方法:
标记:
规格:100ug
供应商:Leinco
价格(RMB):5100.00
订购:
说明书:
Recombinant Human TNF-Related Apoptosis-Inducing Ligand Receptor 4 (TRAIL R4)
Purified No Carrier Protein
(TNFRSF10D, Decoy Receptor 2 (DCR2), CD264, TRUNDD, TR4)
Prod. No.: T403
Source NSO Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C
Description
Background:
TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4) is a decoy receptor that negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 and TRAIL-R2.1 TRAIL R4 is expressed mainly on CD8+ and NK cells and induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4 contains partially truncated death domain and therefore is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing.1,2
Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human TRAIL R4 is Mr 44.2 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 70-80 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
atipr qdevpqqtva pqqqrrslke eecpagshrs eytgacnpct egvdytiasn nlpscllctv cksgqtnkss ctttrdtvcq cekgsfqdkn spemcrtcrt gcprgmvkvs nctprsdikc knesaasstg ktpaaeetvt tilgmlaspy hiegridpks cdkthtcppc papellggps vflfppkpkd tlmisrtpev tcvvvdvshe dpevkfnwyv dgvevhnakt kpreeqynst yrvvsvltvl hqdwlngkey kckvsnkalp apiektiska kgqprepqvy tlppsrdelt knqvsltclv kgfypsdiav ewesngqpen nykttppvld sdgsfflysk ltvdksrwqq gnvfscsvmh ealhnhytqk slslspgkhh hhhh
References
1. Chan FK et al. (2005) Proc Natl Acad Sci USA 102: 18099
2. Sanlioglu S et al. (2005) BMC Cancer 5: 54
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