产品编号:T406-100
产品描述:Recombinant Mouse TRAIL R2
反应种属:
实验方法:
标记:
规格:100ug
供应商:Leinco
价格(RMB):5100.00
订购:
说明书:
Recombinant Mouse TNF-Related Apoptosis-Inducing Ligand Receptor 2 (TRAIL R2)
Purified No Carrier Protein
(TNFRSF10B, CD262, DR5, KILLER, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9)
Prod. No.: T406
Source Sf 21 Insect Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C
Description
Background:
Tumor necrosis factor-related apoptosis-inducing ligand Receptor 2 (TRAIL-R2) is a cell-surface receptor involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling.1 The death ligand TRAIL bears high potential as a new anticancer agent, as binding to the death receptors TRAIL-R1 or TRAIL-R2 triggers apoptosis in most cancer cells.2 TRAIL-R2 has been shown to be associated with a decrease in the survival rates of breast cancer patients.3
Source
Sf 21 Insect Cells
Molecular Weight
The predicted molecular weight of Recombinant Mouse TRAIL R2 is Mr 40 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 49 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
npahnrpa glqrpeesps rgpclagqyl segnckpcre gidytshsnh sldscilctv ckedkvvetr cnittntvcr ckpgtfedkd speicqscsn ctdgeeelts ctprenrkcv sktawas (Mouse TRAIL R2 Arg58-Ser177) ieg rmdpkscdkt htcppcpape llggpsvflf ppkpkdtlmi srtpevtcvv vdvshedpev kfnwyvdgve vhnaktkpre eqynstyrvv svltvlhqdw lngkeykckv snkalpapie ktiskakgqp repqvytlpp srdeltknqv sltclvkgfy psdiavewes ngqpennykt tppvldsdgs fflyskltvd ksrwqqgnvf scsvmhealh nhytqkslsl spgk
References
1. Nam Jin Yoo et al. (2001) Oncogene 20: 399
2. Jürgen Eberle et al. (2005) J Investigative Dermatol. 125: 1010
3. Rimm D et al. (2005) Clin Cancer Research 11
Related Products
Anti-Human TRAIL R2 (Leinco Prod. No.: T451)
Anti-Mouse TRAIL R2 (Antigen Aff. Pur.) (Leinco Prod. No.: T474)
Anti-Human TRAIL R2-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: T497)
Anti-Mouse TRAIL R2-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: T501)
