产品编号:T522-1
产品描述:Recombinant Human TNF RII (aa 24-206) (TNFRSF1B)
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Human Tumor Necrosis Factor Receptor Type II (TNF RII)
Purified No Carrier Protein
(TNFRSF1B, TNFR75, p75, CD120b, TNFR80, p80)
Prod. No.: T522
Source E. coli
Pkg. Size: 1 mg, 25 µg
Storage: -20°C to -70°C
Description
Background:
TNF RII, also known as TNFRSF1B, is a transmembrane glycoprotein and member to the TNF receptor superfamily (1). It is limited primarily to hematopoietic cells and cells of the immune system and is produced naturally as a soluble form (sTNF RII) in various biological fluids (2). The soluble TNF receptor can bind TNF with high affinity and function as a TNF antagonist (3, 4). TNF RII is strongly expressed at the cartilage–pannus junction and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (1, 5). High plasma levels of sTNF RII were associated with increased incidence of coronary heart disease, independent of established cardiovascular risk factors (5). TNF RII has also been implicated in diabetes (6).
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Human TNF RII is Mr 20 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
paqvaft pyapepgstc rlreyydqta qmccskcspg qhakvfctkt sdtvcdsced stytqlwnwv peclscgsrc ssdqvetqac treqnrictc rpgwycalsk qegcrlcapl rkcrpgfgva rpgtetsdvv ckpcapgtfs nttsstdicr phqicnvvai pgnasrdavc tstspt
References
1. Dieudé, P. et al. (2002) Arthritis Care & Res. 46:2039
2. Ziegenhagen, M. W. et al. (2000) J. Int. Med. 248:33
3. Chen, G. et al. (2002) Science 296:1634
4. Chung, A. et al. (2005) Mol. and Cell Biol. 25:4716
5. Wassink, T. H. et al. (2000) Mol. Psych. 5:678
6. Shai, I. et al. (2005) Diabetes Care 28:1376
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