产品编号:T408-50
产品描述:Recombinant Human TNF RII
反应种属:
实验方法:
标记:
规格:50ug
供应商:Leinco
价格(RMB):4725.00
订购:
说明书:
Recombinant Human Tumor Necrosis Factor Receptor II (TNF RII)
Purified No Carrier Protein
(TNFRSF1B, p75, CD120b, TBPII, TNF-R75, TNFBR, TNFR2, TNFR80, p75TNFR)
Prod. No.: T408
Source NSO Cells
Pkg. Size: 1 mg, 50 µg
Storage: -20°C to -70°C
Description
Background:
Tumor necrosis factor receptor II (TNF-RII, TNFRSF1B, p75, CD120b) is a membrane glycoprotein in the TNF receptor superfamily. It is present on most cell types and is considered to play a prominent role in stimulation by TNF-α (1). TNF-RII proteins are expressed by hematopoietic cells including macrophages, neutrophils, lymphocytes, thymocytes and mast cells, as well as endothelial cells, cardiac myocytes and prostate cells (2). Soluble TNF-RII neutralizes the biological activities of TNF-α and TNF-β with equal efficiency (3).
Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human TNF RII is Mr 52.6 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 70 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
lpaqvaft pyapepgstc rlreyydqta qmccskcspg qhakvfctkt sdtvcdsced stytqlwnwv peclscgsrc ssdqvetqac treqnrictc rpgwycalsk qegcrlcapl rkcrpgfgva rpgtetsdvv ckpcapgtfs nttsstdicr phqicnvvai pgnasrdavc tstsptrsma pgavhlpqpv strsqhtqpt pepstapsts fllpmgpspp aegstgdieg rmdpkscdkt htcppcpape llggpsvflf ppkpkdtlmi srtpevtcvv vdvshedpev kfnwyvdgve vhnaktkpre eqynstyrvv svltvlhqdw lngkeykckv snkalpapie ktiskakgqp repqvytlpp srdeltknqv sltclvkgfy psdiavewes ngqpennykt tppvldsdgs fflyskltvd ksrwqqgnvf scsvmhealh nhytqkslsl spgkhhhhhh
References
1. Zuckerman, K. S. et al. (1998) Cancer Res. 58:2217
2. Schall, T. J. et al. (1990) Cell 61:361
3. Tartaglia, L.A. et al. (1992) Immunol. Today 13:151
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