产品编号:T158-25
产品描述:Recombinant Human CCL17
反应种属:
实验方法:
标记:
规格:25ug
供应商:Leinco
价格(RMB):4725.00
订购:
说明书:
Recombinant Human Chemokine (C-C Motif) Ligand 17 (CCL17)
Purified No Carrier Protein
(Thymus and Activation Regulated Chemokine (TARK), A-152E5.3, ABCD-2, MGC138271, MGC138273, SCYA17, TARC, Dendrokine)
Prod. No.: T158
Source E. coli
Pkg. Size: 1 mg, 25 µg
Storage: -20°C to -70°C
Description
Background:
Chemokine (C-C motif) ligand 17 (CCL17) is a small cytokine belonging to the CC chemokine and is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells.1 This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4.1,2 CCL17 may be a useful serological marker and may facilitate an assessment of the degree of disease activity in systemic lupus erythematosus (SLE).3 It may also participate in the pathogenesis of skin diseases such as atopic dermatitis (AD) by regulating both allergic and irritant inflammation.4
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Human CCL17 is Mr 8.0 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human Thymus and Activation Regulated Chemokine is determined by its ability to chemoattract human T cells using a concentration range of 1.0-10.0 ng/ml.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
argtnvg reccleyfkg aiplrklktw yqtsedcsrd aivfvtvqgr aicsdpnnkr vknavkylqs lers
References
1. Yoshie O et al. (1996) J Biol Chem. 271: 21514
2. Yoshie O et al. (1997) J Biol Chem. 272: 15036
3. Naoyuki Kamatani et al. (2003) J Rheumatology 30: 2369
4. Kunihiko K et al. (2006) Eur J Immunol. 36: 2116
Related Products
Anti-Human CCL17 (Leinco Prod. No.: C1404)
Anti-Mouse CCL17 (Leinco Prod. No.: C1435)
Anti-Mouse CCL17 (Leinco Prod. No.: T443)
Anti-Mouse CCL17 (Antigen Aff. Pur.) (Leinco Prod. No.: T464)
Anti-Human CCL17-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: T172)
Anti-Human CCL17 (Antigen Aff. Pur.) (Leinco Prod. No.: T166)
Anti-Mouse CCL17-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: C1510)
