产品编号:S574-1
产品描述:Recombinant Human SMAC
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Human Second Mitochondria Derived Activator of Caspase (SMAC)
Purified No Carrier Protein
(Diablo)
Prod. No.: S574
Source E. coli
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C
Description
Background:
Second Mitochondria Derived Activator of Caspase (SMAC) is a mitochondrial apoptogenic protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs.1 SMAC promotes cytochrome-c dependent activation by eliminating the inhibition of IAP - a protein that negatively regulates apoptosis or programmed cell death.2
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Human SMAC is Mr 22 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and is supplied in a solution of 20 mM Hepes and 0.1 M potassium chloride (KCl), pH 7.5.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one week or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
References
1. Melendez-Zajgla J. et al. (2008) J Exp Clin Cancer Res. 26: 27
2. Vucicet al. (2002) J Biol chem. 277: 12275
Related Products
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Anti-Human SMAC (CT) (Leinco Prod. No.: S483)
Anti-Human SMAC (Antigen Aff. Pur.) (Leinco Prod. No.: S585)
Anti-Human SMAC-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: S592)
