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Recombinant Human SIGIRR

产品编号:S575-100

产品描述:Recombinant Human SIGIRR

反应种属:

实验方法:

标记:

规格:100ug

供应商:Leinco

价格(RMB):4800.00

订购:订购

说明书:

Recombinant Human Single Immunoglobulin Domain-Containing IL-1 Receptor-Related Protein (SIGIRR)
Purified No Carrier Protein
(Single Ig IL-1R-related Molecule, MGC110992, TIR8)
Prod. No.: S575
Source NSO Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C

Description
Background:

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR is a member of the IL-1 receptor family.1 It acts as a negative regulator of interleukin (IL)-1 and lipopolysaccharide (LPS) signaling.2 It also plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium.3

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human SIGIRR is Mr 39 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55-60 kDa.
State of Matter
Lyophilized
Purity
>90% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<0.1 ng per 1 µg as determined by the LAL method
Amino Acid Sequence

mpgvcdrapd flspsedqvl rpalgssval nctawvvsgp hcslpsvqwl kdglplgigg hyslheyswv kanlsevlvs svlgvnvtst evygaftcsi qnisfssftl qragptshks cdkthtcppc papellggps vflfppkpkd tlmisrtpev tcvvvdvshe dpevkfnwyv dgvevhnakt kpreeqynst yrvvsvltvl hqdwlngkey kckvsnkalp apiektiska kgqprepqvy tlppsrdelt knqvsltclv kgfypsdiav ewesngqpen nykttppvld sdgsfflysk ltvdksrwqq gnvfscsvmh ealhnhytqk slslspgk

References
1. Mantovani A.et al. (2003) Eur Cytokine Netw. 14: 211
2. Li xet al. (2005) J Biol chem. 280: 25233
3. Li X et al. (2007) Immunity 26: 461
Related Products
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Anti-Human SIGIRR-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: S578)
Anti-Human SIGIRR (Antigen Aff. Pur.) (Leinco Prod. No.: S580)
Recombinant Mouse SIGIRR (Leinco Prod. No.: S576)