产品编号:R135-1
产品描述:Recombinant Mouse RANTES
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Mouse Regulation Upon Activation Normal T Cell Express Sequence (RANTES)
Purified No Carrier Protein
(CCL5, D17S136E, MGC17164, SCYA5, SIS-Delta, TCP228)
Prod. No.: R135
Source E. coli
Pkg. Size: 1 mg, 25 µg
Storage: -20°C to -70°C
Description
Background:
RANTES also known as Chemokine (C-C motif) ligand 5 (CCL5), a CC-chemokine1 is an important mediators of the immune and inflammatory response.2 It is also a potent chemoattractant for T cells 3 and eosinophils.4 RANTES is involved in many inflammatory diseases, for example, bronchial asthma, delayed-type hypersensitivity reactions, viral infections, arthritis, chronic eosinophilic pneumonia, and idiopathic interstitial pneumonia.5
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Mouse RANTES is Mr 7.9 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA) with trehalose.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse RANTES was determined by its ability to chemoattract 2 day cultured human monocytes or mouse BaF3 cells transfected with human CCR5. The expected ED50 for these effects are typically 30 - 100 ng/ml and 7 - 35 ng/ml, respectively.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
spygsdttpc cfaylslalp rahvkeyfyt sskcsnlavv fvtrrnrqvc anpekkwvqe yinylems
rences
1. Lee SC et al. (2004) J Neurochem. 90: 297
2. Borkowski J et al. (2004) Arch Immunol Ther Exp (Warsz) 52: 201
3. Geiger H et al. (2005) Kidney Blood Press Res 28: 48
4. Hirata I. et al. (2008) Dig Dis Sci.
5. Emilie D et al. (1994) J Exp Med. 179: 1689
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