产品编号:P168-1
产品描述:Recombinant Human Prolactin(PRL)
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Human Prolactin (PRL)
Purified No Carrier Protein
(Mammotropin, Luterotropic Hormone (LTH), Lutetropin)
Prod. No.: P168
Source E. coli
Pkg. Size: 1 mg, 50 µg
Storage: -20°C to -70°C
Description
Background:
Prolactin (PRL) or Luteotropic hormone (LTH) is best known as the pituitary modulator of lactation and reproduction.1 Prolactin is a multifaceted hormone that is capable of modulating hundreds of physiological processes in adult vertebrates.2 PRL promotes proliferation, survival and migration of cancer cells acting via the prolactin receptor (PRLR).3 It also modulates maternal behavior and mediates hypothalamic pituitary adrenal axis inhibition during lactation via PRL receptors in the brain.4 Prolactin also has a number of other effects including contributing to surfactant synthesis of the fetal lungs at the end of the pregnancy and immune tolerance of the fetus by the maternal organism during pregnancy. It also decreases normal levels of sex hormones — estrogen in women and testosterone in men.5
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Human PRL is Mr 24 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human PRL was measured in a cell proliferation assay using the rat lymphoma, Nb2-11 (Gout, P.W. et al., 1980, Cancer Research 40:2433 - 2436). The expected ED50 for this effect is typically 0.03 - 0.1 ng/ml.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
mlp icpggaarcq vtlrdlfdra vvlshyihnl ssemfsefdk rythgrgfit kainschtss latpedkeqa qqmnqkdfls livsilrswn eplyhlvtev rgmqeapeai lskaveieeq tkrllegmel ivsqvhpetk eneiypvwsg lpslqmadee srlsayynll hclrrdshki dnylkllkcr iihnnnc
References
1. Paus R et al. (2008) J Invest Dermatol.
2. Zhu Y et al. (2008) Comp Biochem Physiol A Mol Integr Physiol
3. Panina S et al. (2009) J Endocrinol
4. Neuwmann ID et al. (2008) Endocrinology
5. (2008) Mayo Clinic
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