Cadherin 3, type 1, Placental-cadherin (P-cad), also known as CDH3 is a transmembrane protein involved in the cell-cell contact surface of basal keratinocytes and is homologous to E-cadherin.¹ P-cad is expressed in placenta, epithelia, the basal cell of the skin, playing an important role in the morphogenesis of epidermis and skin appendage. The expression of P-cad in epithelial tissues appears to identify cell populations with proliferative activity, and its expression decreases as cells differentiate.¹ P-cadherin, expressed in normal breast myoepithelial cells, has been reported in breast carcinomas, where it is associated with high-grade histological tumors and proliferation.²

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