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Recombinant Human OTOR

产品编号:O106-1

产品描述:Recombinant Human OTOR

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:订购

说明书:

Recombinant Human Otoraplin (OTOR)
Purified No Carrier Protein
(OTOR, Fibrocyte-Derived Protein (FDP), MGC126737, MGC126739, MIAL, MIAL1)
Prod. No.: O106
Source E. coli
Pkg. Size: 1 mg, 5 µg, 20 µg
Storage: -20°C

Description
Background:

Otoraplin, also known as OTOR is a secreted cytokine that is expressed predominantly in the cochlea of the inner ear and to a lesser extent in fetal brain and in some cartilage tissues. OTOR may play a role in chondrogenesis of the otic capsule as reduction of its expression by suitable antisense oligonucleotides causes a significant reduction in chondrogenesis.1 Otoraplin is homologous to the protein encoded by CDRAP/MIA (cartilage-derived retinoic acid sensitive protein/melanoma inhibitory activity), which is expressed predominantly by chondrocytes, functions in cartilage development and maintenance, and has growth-inhibitory activity in melanoma cell lines.2

Source
E. coli
Molecular Weight
The molecular weight of Recombinant Human OTOR is Mr 12.7 kDa.
State of Matter
Lyophilized
Purity
>95% by SDS Page and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. For long-term storage of the reconstituted protein, it is recommended to add a carrier protein such as 0.1% BSA, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<0.1 EU/µg as determined by the LAL method
Amino Acid Sequence

MVHGIFMDRL ASKKLCADDE CVYTISLASA QEDYNAPDCR FINVKKGQQI YVYSKLVKEN GAGEFWAGS VYGDGQDEMG VVGYFPRNLV KEQRVYQEAT KEVPTTDIDF FCE

References
1. Cohen-Salmon M. et al. (2000) J of Biol. Chem. 275: 40036
2. Morton CC. et al. (2000) Genomics 66: 242