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Recombinant Mouse Osteopontin(OPN)

产品编号:O121-1

产品描述:Recombinant Mouse Osteopontin(OPN)

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:订购

说明书:

Recombinant Mouse Osteopontin(OPN)
Purified No Carrier Protein
(Secreted Phosphoprotein 1 (SPP1), BNSP, Bone Sialoprotein I (BSPI), ETA-1, MGC110940)
Prod. No.: O121
Source NSO Cells
Pkg. Size: 1 mg, 50 µg, 200 µg
Storage: -20°C to -70°C 

Description
Background:

Osteopontin (OPN) also known as bone sialoprotein I (BSP-1), early T-lymphocyte activation (ETA-1), and Secreted phosphoprotein 1 (SPP1) is a secreted phosphoprotein that confers on cancer cells a migratory phenotype and activates signaling pathways that induce cell survival, proliferation, invasion, and metastasis.1 OPN is also considered as a proinflammatory cytokine.2 OPN has been studied as a multifunctional protein that is upregulated in a variety of acute and chronic inflammatory conditions, such as wound healing, fibrosis, autoimmune disease, and atherosclerosis. OPN is highly expressed at sites with atherosclerotic plaques, especially those associated with macrophages and foam cells.3

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Mouse Osteopontin is Mr 31.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 65 dKa doublet and a 30 kDa band.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

lpvk vtdsgsseek lyslhpdpia twlvpdpsqk qnllapqnav sseekddfkq etlpsnsnes hdhmdddddd ddddgdhaes edsvdsdesd eshhsdesde tvtastqadt ftpivptvdv pngrgdslay glrsksrsfq vsdeqypdat dedltshmks geskesldvi pvaqllsmps dqdnngkgsh essqldepsl ethrlehske sqesadqsdv idsqasskas lehqshkfhs hkdklvldpk skeddrylkf rishelesss sevnhhhhhh

References
1. Arafat H et al. (2009) Int J Cancer
2. Xue S et al. (2009) Heart Vessels 24: 116
3. Kim HS et al. (2009) Curr Atheroscler Rep. 11: 206
Related Products
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Anti-Mouse Osteopontin-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: O135)