产品编号:N175-1
产品描述:Recombinant Human Neuroserpin
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
说明书:
Recombinant Human Neuroserpin
Purified No Carrier Protein
(Serpin I1, Protease Inhibitor 12 (PI-12))
Prod. No.: N175
Source E. coli
Pkg. Size: 1 mg, 25 µg
Storage: -20°C
Neuroserpin is an axonally secreted serine proteinase inhibitor that is expressed in neurons during embryogenesis and in the adult nervous system1 and is implicated in the regulation of proteases involved in processes such as synaptic plasticity, neuronal migration and axogenesis.2 Neuroserpin plays a neuroprotective role, by blocking the deleterious effects of proteolytic enzymes such as tissue plasminogen activator (tPA). A familial form of a neurodegenerative disease, termed familial encephalopathy with neuroserpin inclusion bodies, is caused by the intracellular polymerization and accumulation of mutated neuroserpin, leading to neuronal death and dementia.3
MTGATFPEEA IADLSVNMYN RLRATGEDEN ILFSPLSIAL AMGMMELGAQ GSTQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQ NGFHVNEEFL QMMKKYFNAA VNHVDFSQNV AVANYINKWV ENNTNNLVKD LVSPRDFDAA TYLALINAVY FKGNWKSQFR PENTRTFSFT KDDESEVQIP MMYQQGEFYY GEFSDGSNEA GGIYQVLEIP YEGDEISMML VLSRQEVPLA TLEPLVKAQL VEEWANSVKK QKVEVYLPRF TVEQEIDLKD VLKALGITEI FIKDANLTGL SDNKEIFLSK AIHKSFLEVN EEGSEAAAVS GMIAISRMAV LYPQVIVDHP FFFLIRNRRT GTILFMGRVM HPETMNTSGH DFEEL