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Recombinant Human Neuroserpin

产品编号:N175-1

产品描述:Recombinant Human Neuroserpin

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:订购

说明书:

Recombinant Human Neuroserpin
Purified No Carrier Protein
(Serpin I1, Protease Inhibitor 12 (PI-12))
Prod. No.: N175
Source E. coli
Pkg. Size: 1 mg, 25 µg
Storage: -20°C 

Description
Background:

Neuroserpin is an axonally secreted serine proteinase inhibitor that is expressed in neurons during embryogenesis and in the adult nervous system1 and is implicated in the regulation of proteases involved in processes such as synaptic plasticity, neuronal migration and axogenesis.2 Neuroserpin plays a neuroprotective role, by blocking the deleterious effects of proteolytic enzymes such as tissue plasminogen activator (tPA). A familial form of a neurodegenerative disease, termed familial encephalopathy with neuroserpin inclusion bodies, is caused by the intracellular polymerization and accumulation of mutated neuroserpin, leading to neuronal death and dementia.3

Source
E. coli
Molecular Weight
The molecular weight of Recombinant Human Neuroserpin is Mr 44.6 kDa.
State of Matter
Lyophilized
Purity
>96% by HPLC analysis
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<1.0 EU/µg
Biological Activity
The biological activity of Human Neuroserpin was determined by its ability to stimulate the proliferation of Rat C6 cells in the range of 0.5 - 0.6 ug/ml.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence

MTGATFPEEA IADLSVNMYN RLRATGEDEN ILFSPLSIAL AMGMMELGAQ GSTQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQ NGFHVNEEFL QMMKKYFNAA VNHVDFSQNV AVANYINKWV ENNTNNLVKD LVSPRDFDAA TYLALINAVY FKGNWKSQFR PENTRTFSFT KDDESEVQIP MMYQQGEFYY GEFSDGSNEA GGIYQVLEIP YEGDEISMML VLSRQEVPLA TLEPLVKAQL VEEWANSVKK QKVEVYLPRF TVEQEIDLKD VLKALGITEI FIKDANLTGL SDNKEIFLSK AIHKSFLEVN EEGSEAAAVS GMIAISRMAV LYPQVIVDHP FFFLIRNRRT GTILFMGRVM HPETMNTSGH DFEEL

References
1. Peter Sonderegger et al. (1998) Ame Society of Biochem. Molec. Biol. 273: 2312
2. Birch NP. et al. (2002) J Neurochem. 80: 1406
3. Sonderegger P. et al. (2006) Front Bioscie. 11: 33
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