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Recombinant Mouse MMP-2

产品编号:M1255-10

产品描述:Recombinant Mouse MMP-2

反应种属:

实验方法:

标记:

规格:10ug

供应商:Leinco

价格(RMB):5475.00

订购:订购

说明书:

Recombinant Mouse Matrix Metalloproteinase-2 (MMP-2)
Purified No Carrier Protein
(CLG4, CLG4A, MMP-II, MONA, TBE-1)
Prod. No.: M1255
Source NSO Cells
Pkg. Size: 1 mg, 10 µg
Storage: -20°C to -70°C

Description
Background:

Matrix metallopeptidase 2, also known as MMP2, is an enzyme involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP-2 degrades type IV collagen, the major structural component of basement membranes and plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. MMP2 has been found to be associated with tumor invasion in various cancers.1

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Mouse MMP-2 is Mr 71 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 72 kDa.
State of Matter
Solution
Formulation
Supplied as a 0.2 μm filtered solution of 25 mM Tris, pH 7.5, 5 mM CaCl2, 75 mM NaCl, 0.025% Brij-35 and 50% glycerol at a concentration of 0.113 mg/ml.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This protein is stable for one month when stored sterile at -20°C or for three months when stored at -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Biological Activity
The specific activity, measured under the described conditions, is > 1,500 pmoles/min/μg.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence

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References
1. Melissa Schorr et al. (2005) Medscape Medical News
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