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Recombinant Human MMP-1

产品编号:M1250-10

产品描述:Recombinant Human MMP-1

反应种属:

实验方法:

标记:

规格:10ug

供应商:Leinco

价格(RMB):5475.00

订购:订购

说明书:

Recombinant Human Matrix Metalloproteinase-1 (MMP-1)
Purified No Carrier Protein
(Collagenase (CLGN), CLG, Collagenase-1 (CLG1), Fibroblast Collagenase, Fibroblast-Type Collagenase, Interstitial Collagenase, Tissue Collagenase)
Prod. No.: M1250
Source NSO Cells
Pkg. Size: 1 mg, 10 µg
Storage: -20°C to -70°C

Description
Background:

Matrix metallopeptidase 1 (interstitial collagenase), also known as MMP1 is an enzyme involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP-1 is the only enzyme able to initiate breakdown of the interstitial collagens, collagen type 1, collagen type 2, and collagen type 3.1,2 MMP-1 plays an important role in diverse physiologic processes such as development, tissue morphogenesis, and wound repair. Expression of MMP-1 is a prognostic marker for hematogenous metastasis of colorectal cancer.3

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human MMP-1 is Mr 52 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 52-55 kDa.
State of Matter
Solution
Formulation
This recombinant protein was 0.2 µm filtered and is supplied in a solution of sodium chloride (NaCl), calcium chloride (CaCl2), MES and Brij-35.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
Working aliquots of this recombinant protein solution are stable for up to six months at -20°C to -70°C in a manual defrost freezer. Upon thawing, in the presence of a carrier protein, this recombinant protein can be stored at -20°C to -70°C for three months without detectable loss of activity. For long-term storage, aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

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References
1. Brinckerhoff et al. (1987) Oncology 64: 337
2. Saffarian et al. (2004) Science 306: 108
3. Sunami E. et al. (1987) Oncologist 5: 108
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