产品编号:M1122-20
产品描述:Recombinant Rat MIP-1β
反应种属:
实验方法:
标记:
规格:20ug
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Rat Macrophage Inflammatory Protein-1 Beta (MIP-1β)
Purified No Carrier Protein
(CCL4, ACT2, AT744.1, G-26, LAG1, MGC104418, MGC126025, MGC126026, MIP1B1, SCYA2, SCYA4)
Prod. No.: M1122
Source E. coli
Pkg. Size: 20 µg, 5 µg
Storage: -20°C - -70°C
Description
Background:
Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells.
Source
E. coli
Molecular Weight
The molecular weight of Recombinant Rat MIP-1β is Mr 7.8 kDa.
State of Matter
Lyophilized
Formulation
The recombinant protein is provided lyophilized with no additives.
Purity
>98% by SDS Page and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Rat Macrophage Inflammatory Protein-1 Beta is determined by its ability to chemoattract human monocytes using a concentration range of 0.01-1.0 µg/ml.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
APIGSDPPTS CCFSYTSRKI HRNFVMDYYE TSSLCSQPAV VFLTKKGRQI CADPSEPWVN EYVNDLELN
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