产品编号:M162-50
产品描述:Recombinant Human MIP-1β
反应种属:
实验方法:
标记:
规格:50ug
供应商:Leinco
价格(RMB):11925.00
订购:
说明书:
Recombinant Human Macrophage Inflammatory Protein-1 Beta (MIP-1β)
Purified No Carrier Protein
(CCL4, ACT2, AT744.1, G-26, LAG1, MGC104418, MGC126025, MGC126026, MIP1B1, SCYA2, SCYA4)
Prod. No.: M162
Source E. coli
Pkg. Size: 1 mg, 10 µg, 50 µg
Storage: -20°C to -70°C
Description
Background:
Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells.
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Human MIP-1β is Mr 7.8 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human MIP-1β was determined by its ability to chemoattract mouse BaF/3 cells transfected with human CCR5. The expected ED50 for this effect is typically 3 - 10 ng/ml.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
apmgsdp ptaccfsyta rklprnfvvd yyetsslcsq pavvfqtkrs kqvcadpses wvqeyvydle ln
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