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Recombinant Mouse MAdCAM-1

产品编号:M1257-1

产品描述:Recombinant Mouse MAdCAM-1

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:订购

说明书:

Recombinant Mouse Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1)
Purified No Carrier Protein
Prod. No.: M1257
Source NSO Cells
Pkg. Size: 1 mg, 50 µg
Storage: -20°C to -70°C

Description
Background:

Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a multifunctional type l transmembrane adhesion molecule that is expressed selectively at venular sites of lymphocyte extravasation into mucosal lymphoid tissues and lamina propria, where it directs local lymphocyte trafficking.1 MAdCAM-1 is involved in the normal recirculation of lymphocytes between the blood and the gastrointestinal tract.2 MAdCAM-1 may be a relevant tissue-specific therapeutic target for the modulation of inflammatory bowel disease activity.3

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Mouse MAdCAM-1 is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 85-95 kDa.
State of Matter
Lyophilized
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

qsfqvnppes evavamgtsl qitcsmscde gvarvhwrgl dtslgsvqtl pgssilsvrg mlsdtgtpvc vgscgsrsfq hsvkilvyaf pdqlvvspef lvpgqdqvvs ctahniwpad pnslsfalll geqrlegaqa lepeqeeeiq eaegtplfrm tqrwrlpslg tpappalhcq vtmqlpklvl thrkeipvlq sqtspkppnt tsaepyilts sstaeavstg lnittlpsap pypklsprtl ssegpcrpki hqdleagwel lceascgpgv tvrwtlapgd latyhkreag aqawlsvlpp gpmvegwfqc rqdpggqvtn lyvpgqvtpn ssstkscdkt htcppcpape llggpsvflf ppkpkdtlmi srtpevtcvv vdvshedpev kfnwyvdgve vhnaktkpre eqynstyrvv svltvlhqdw lngkeykckv snkalpapie ktiskakgqp repqvytlpp srdeltknqv sltclvkgfy psdiavewes ngqpennykt tppvldsdgs fflyskltvd ksrwqqgnvf scsvmhealh nhytqkslsl spgk

References
1. Briskin MJ et al. (1995) J Immunol. 155: 2477
2. Jackson D et al. (1997) Immunol Res. 16: 299
3. Ringler DJ et al. (1997) Am J Pathol. 151: 97