Myelin-associated glycoprotein (MAG) is a transmembrane proteins that is a component of myelin in the central and peripheral nervous system.¹ It promotes neurite outgrowth during the embryonic development, but inhibits axonal regeneration in the adult nervous system.¹ MAG mediates cell-cell interactions between myelinating glial cells and neurons.² MAG as an important component of the myelin-derived inhibition of nerve regeneration. The acute loss of MAG function can promote significant axon growth across a site of CNS nerve damage.⁴

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