Macrophage colony-stimulating factor (M-CSF, also termed CSF-1) receptor is an integral membrane tyrosine kinase, expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage.^1,2,3 It also triggers growth and development of mononuclear phagocytes and placental trophoblasts.⁴ M-CSF receptor is present in osteoclasts both at mRNA and protein levels. When M-CSF ligand specifically binds to the M-CSF receptor on osteoclasts, it induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues⁵ M-CSF and its receptor present as candidate therapeutic targets in states of inflammatory bone erosion.⁶

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