产品编号:M1227-10
产品描述:Recombinant Rat M-CSF
反应种属:
实验方法:
标记:
规格:10ug
供应商:Leinco
价格(RMB):5130.00
订购:
说明书:
Recombinant Rat Macrophage Colony Stimulating Factor (M-CSF)
Purified No Carrier Protein
(CSF-1, MGI-IM, MGC31930)
Prod. No.: M1227
Source E. coli
Pkg. Size: 1 mg, 10 µg
Storage: -20°C
Description
Background:
Macrophage colony-stimulating factor, or M-CSF, is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. M-CSF is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. It enhances cytotoxicity, superoxide production, phagocytosis, chemotaxis, and secondary cytokine production in monocytes and macrophages.1 It binds to the Colony stimulating factor 1 receptor. M-CSF is known as one of the factors essential for osteoclast development.2
Source
E. coli
Molecular Weight
The molecular weight of Recombinant Rat M-CSF is Mr 18.1 kDa.
State of Matter
Lyophilized
Purity
>98% by SDS Page and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<1.0 EU/µg
Biological Activity
The biological activity of Rat Macrophage Colony Stimulating Factor is determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells. The ED50 is < 5.0 ng/ml, corresponding to a specific activity of > 1 x 105 units/mg.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
MEVSEHCSHM IGNGHLQILQ QLIDSQMETA CLIEYKFVDQ EQLDDPVCYL KKAFVLVQVI IEETMRFKDN TPNANATERL QELSMKLNSC FIKDYKEQNE ACVQTYKESP LRLLEKIKNF FNETKNFLEK DWNIFSKNCN DSLAKCSSRD VVTKP
References
1. Nemunaitis J. et al. (1998) Clin. Infect. Dis. 26: 1279
2. Ko JS. et al. (2002) Exp Mol Med 34: 340
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