产品编号:L181-1
产品描述:Recombinant Chicken Leptin
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Chicken Leptin
(Obesity Protein (OB), B219, LEP, OBS)
Prod. No.: L181
Source E. Coli
Pkg. Size: 1 mg, 100 µg, 200 µg
Storage: -20°C
Description
Background:
Leptin is a neuroendocrine hormone secreted from adipose tissue that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin is one of the most important adipose derived hormones.1 It interacts with six types of receptors and once it binds to OB-Receptor it activates the stat3, which is phosphorylated and travels to the nucleus to effect changes in gene expression. One of the main effects on gene expression is the down-regulation of the expression of endocannabinoids.2 High leptin levels are associated with psoriasis.3
Source
E. Coli
State of Matter
Purity
>95% by SDS Page and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<0.125 EU/µg
Biological Activity
Biological active as evidenced by inducing proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Val-Pro-Ile-Arg.
References
1. Mantzoros CS et al.(2006) Nat Clin Pract Endocrinol Metab. 2: 318
2. Hill RA. et al.(2002) Int. J. Obes. Relat. Metab. Disord. 26: 1407
3. Chen Y-J. et al.(2008) Arch Derm. 144: 1571
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