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Recombinant Human IL-15 Rα

产品编号:I-543-100

产品描述:Recombinant Human IL-15 Rα

反应种属:

实验方法:

标记:

规格:100ug

供应商:Leinco

价格(RMB):4725.00

订购:订购

说明书:

Recombinant Human Interleukin-15 Rα (IL-15 Rα)
Purified No Carrier Protein
(IL15RA, MGC104179)
Prod. No.: I-543
Source Sf 21 Insect Cells
Pkg. Size: 1 mg , 100 µg
Storage: -20°C to -70°C

Description
Background:

Interleukin 15 receptor, alpha (IL15RA) is a subunit of the IL-15 receptor and specifically binds to IL-15. It is expressed in a wide variety of T cells and B cells, as well as, non-lymphoid cells. The receptors of IL-15 and IL-2 share two subunits, the IL-2R beta and IL-2R gamma chains (1). This forms the basis of many overlapping biological activities of IL-15 and IL-2 (2). IL15RA is structurally related to IL2RA but is capable of binding IL-15 with high affinity independent of other subunits, which suggests the distinct roles between IL-15 and IL-2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2 (3). The binding of IL-15 to IL15RA antagonizes the TNF-alpha-mediated apoptosis in fibroblasts by competing with TNRF1 for TRAF2 binding (4).

Source
Sf 21 Insect Cells
Molecular Weight
The predicted molecular weight of Recombinant Human IL-15 Rα is Mr 42.6 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 60-70 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

itcpppmsve hadiwvksys lysreryicn sgfkrkagts sltecvlnka tnvahwttps lkcikpaass pssnntaatt aaivpgsqlm pskspstgtt eisshesshg tpsqttaknw eltasashqp pgvypqghsd ttiegrdmdp kscdkthtcp pcpapellgg psvflfppkp kdtlmisrtp evtcvvvdvs hedpevkfnw yvdgvevhna ktkpreeqyn styrvvsvlt vlhqdwlngk eykckvsnka lpapiektis kakgqprepq vytlppsrde ltknqvsltc lvkgfypsdi avewesngqp ennykttppv ldsdgsffly skltvdksrw qqgnvfscsv mhealhnhyt qkslslspgk hhhhhh

References
1. Giri, J. G. et al. (1995) EMBO J. 14:3654
2. Anderson, D. M. et al. (1995) J. Biol. Chem. 270:29862
3. Wu, T. S. et al. (2002) Immunol. 168:705
4. Bulfone-Paus, S. et al. (1999) FASEB 13:1575
Related Products
Recombinant Human IL-15 Rα (Leinco Prod. No.: I-549)
Anti-Human IL-15 Rα (Antigen Aff. Pur.) (Leinco Prod. No.: I-613)
Anti-Human IL-15 Rα (Leinco Prod. No.: I-626)