产品编号:I-813-1
产品描述:Recombinant Rat IL-17E
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Rat Interleukin-17E (IL-17E)
Purified No Carrier Protein
(IL25)
Prod. No.: I-813
Source E. coli
Pkg. Size: 1 mg, 2 µg, 10 µg, 100 µg
Storage: -20°C
Description
Background:
Interleukin (IL)-17E, is a novel member of the IL-17 family of cytokines1 and a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses.2 IL17B is also a ligand for the cytokine receptor IL17BR. IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8. 1 IL-17E may contribute to the induction and maintenance of eosinophilic inflammation in the airways by acting on lung fibroblasts and therefore has a role in asthma pathophysiology.3
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Rat IL-17E is Mr 35.5 kDa.
State of Matter
Lyophilized
Formulation
The protein was 0.2 µm filtered and lyophilized with no additives.
Purity
>97% by SDS-PAGE and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Rat IL-17E was determined by the dose -dependent induction of mG-CSF production in cultured NIH 3T3 cells. The dose range for this activity is 10-100 ng/ml.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
CSHLPRCCPS KQQEFPEEWL KWNPAPVSPP EPLRHTHHPE SCRASKDGPL NSRAISPWSY ELDRDLNRVP QDLYHARCLC PHCVSLQTGS HMDPMGNSVP LYHNQTVFYR RPCHGEQGAH GRYCLERRLY RVSLACVCVR PRMMA
References
1. Gurney AL. et al. (2001) J Biol Chem. 276: 1660
2. Gurney AL. et al. (2001) J Immunol. 167: 6559
3. Hamid Q. et al. (2006) J Allergy Clin. Immunol. 117: 590
Related Products
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Recombinant Human IL-17E (Leinco Prod. No.: I-199)
Human IL-17E ELISA Development Kit (Leinco Prod. No.: I-412)
Recombinant Mouse IL-17E (Leinco Prod. No.: I-850)
