产品编号:I-278-5
产品描述:Recombinant Mouse IL-13
反应种属:
实验方法:
标记:
规格:5ug
供应商:Leinco
价格(RMB):4125.00
订购:
说明书:
Recombinant Mouse Interleukin-13 (IL-13)
Purified No Carrier Protein
(ALRH, BHR1, MGC116786, P600, NC30)
Prod. No.: I-278
Source E. coli
Pkg. Size: 1 mg, 5 µg, 25 µg
Storage: -20°C to -70°C
Description
Background:
Interleukin 13 (IL-13) is a cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells1, that is an important mediator of allergic inflammation and disease. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα), which is also a component of the IL-4 receptor, and at least one of two known IL-13-specific binding chains.1 The functions of IL-13 overlap considerably with those of IL-4. Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Mouse IL-13 is Mr 11.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 9 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
svslpltlke lieelsnitq dqtplcngsm vwsvdlaagg fcvaldsltn isncnaiyrt qrilhglcnr kapttvsslp dtkievahfi tkllsytkql frhgpf
References
1. Wynn TA. et al. (2003) Annu Rev Immunol. 21: 425
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