Interleukin 12 receptor, beta 1 (IL12RB1), also known as CD212, is a type I transmembrane protein that belongs to the gp130/G-CSF receptor family. It is a common subunit of both the IL-12 and IL-23 receptor complexes which play roles in T cell mediated inflammatory reactions (1). IL12RB1 binds IL-12 with low affinity and is involved in IL-12 transduction (2). In association with IL23R, it forms the IL-23 receptor complex which functions in IL-23 signal transduction probably through activation of the Jak-STAT signaling cascade (3). IL12RB1 is expressed on activated T cells, B cells, NK cells, macrophages, and microglia. Defects in IL12RB1 are generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species (4). Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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