Interleukin 12 (IL-12, NK cell stimulatory factor, cytotoxic lymphocyte maturation factor) is a heterodimeric cytokine that is naturally produced by dendritic cells¹ , macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th1 cells, which is important in resistance against pathogens. It is known as a T cell stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 also has anti-angiogenic activity, which can block the formation of new blood vessels. IL-12 binds to the IL-12 receptor and upon binding, IL-12R-β2 becomes tyrosine phosphorylated and provides binding sites for kinases, Tyk2 and Jak2. These are important in activating critical transcription factor proteins such as STAT4 which are implicated in IL-12 signaling in T cells and NK cells.² IL-12 contributes to the antimycobacterial immune response by enhancing production of interferon-gamma, facilitating development of Th1 cells and augmenting cytotoxicity of antigen-specific T cells and natural killer cells.³

mwelekdv yvvevdwtpd apgetvnltc dtpeedditw tsdqrhgvig sgktltitvk efldagqytc hkggetlshs hlllhkkeng iwsteilknf knktflkcea pnysgrftcs wlvqrnmdlk fniksssssp dsravtcgma slsaekvtld qrdyekysvs cqedvtcpta eetlpielal earqqnkyen ystsffirdi ikpdppknlq mkplknsqve vsweypdsws tphsyfslkf fvriqrkkek mketeegcnq kgaflvekts tevqckggnv cvqaqdryyn sscskwacvp crvrs (p40) rvipvsgp arclsqsrnl lkttddmvkt areklkhysc taedidhedi trdqtstlkt clplelhkne sclatretss ttrgsclppq ktslmmtlcl gsiyedlkmy qtefqainaa lqnhnhqqii ldkgmlvaid elmqslnhng etlrqkppvg eadpyrvkmk lcillhafst rvvtinrvmg ylssa (p35)