产品编号:I-213-50
产品描述:Recombinant Rat IL-6
反应种属:
实验方法:
标记:
规格:50ug
供应商:Leinco
价格(RMB):9675.00
订购:
说明书:
Recombinant Rat Interleukin-6 (IL-6)
Purified No Carrier Protein
(BSF2, HPGF, HSF, IFNB2, MGI-2, HGF, B Cell Differentiation Factor [BCDF])
Prod. No.: I-213
Source E. coli
Pkg. Size: 1 mg, 10 µg, 50 µg
Storage: -20°C to -70°C
Description
Background:
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction.1 It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. Additionally, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6s role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10. IL16 has been shown to suppress the replication of HIV and SIV.2
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Rat IL-6 is Mr 22 kDa.
State of Matter
Solution
Formulation
This recombinant protein was 0.2 µm filtered and is supplied in a solution of 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This recombinant protein can be stored at 2° to 8°C as supplied for six months. Do not freeze.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
mfptsqvrrg dftedtthnr pvyttsqvgg lityvlreil emrkelcngn sdcmnsddal sennlklpei qrndgcfqtg ynqeicllki csgllefrfy lefvknnlqd nkkdkarviq sntetlvhif kqeikdsyki vlptptsnal lmeklesqke wlrtktiqli lkaleeflkv tmrstrqt
References
1. Pederson BK et al. (2005) Exerc Sport Sci Rev 33: 114
2. Baier M. et al. (1997) Proceedings of the National Academy of Sciences (USA) 94: 5273
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