产品编号:I-208-25
产品描述:Recombinant Mouse IL-6
反应种属:
实验方法:
标记:
规格:25ug
供应商:Leinco
价格(RMB):11400.00
订购:
说明书:
Recombinant Mouse Interleukin-6 (IL-6)
Purified No Carrier Protein
(BSF2, HPGF, HSF, IFNB2, MGI-2, HGF, B Cell Differentiation Factor [BCDF])
Prod. No.: I-208
Source E. coli
Pkg. Size: 1 mg, 5 µg, 25 µg
Storage: -20°C to -70°C
Description
Background:
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction.1 It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. Additionally, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6s role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10. IL16 has been shown to suppress the replication of HIV and SIV.2
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Mouse IL-6 is Mr 21.8 kDa.
State of Matter
Solution
Formulation
This recombinant protein was 0.2 µm filtered and is supplied in a solution of 50 mM sodium acetate (NaOAc) and EDTA.
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
mfptsqvrrg dftedttpnr pvyttsqvgg lithvlweiv emrkelcngn sdcmnnddal aennlklpei qrndgcyqtg ynqeicllki ssglleyhsy leymknnlkd nkkdkarvlq rdtetlihif nqevkdlhki vlptpisnal ltdklesqke wlrtktiqfi lksleeflkv tlrstrqt
References
1. Pederson BK et al. (2005) Exerc Sport Sci Rev 33: 114
2. Baier M. et al. (1997) Proceedings of the National Academy of Sciences (USA) 94: 5273
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