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Recombinant Human IL-1 Rrp2

产品编号:I-593-100

产品描述:Recombinant Human IL-1 Rrp2

反应种属:

实验方法:

标记:

规格:100ug

供应商:Leinco

价格(RMB):6300.00

订购:订购

说明书:

Recombinant Human Interleukin-1 Receptor Related Protein 2 (IL-1 Rrp2)
Purified No Carrier Protein
(IL-1 R6)
Prod. No.: I-593
Source Sf 21 Insect Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C 

Description
Background:

Interleukin-1 receptor related protein 2 (IL-1 Rrp2) is a receptor for IL-1F6 which is a proinflammatory member of IL-1 family. IL-1F8, and IL-1F9 also signal through IL-1Rrp2 and IL-1RAcP.1 IL-1F6, IL-1F8 and Il-1F9 are agonists and, along with their receptor IL-1Rrp2, are highly expressed in epithelial cells suggesting a role in immune defense in the skin and the gastrointestinal (GI) tract including the mouth. Synovial fibroblasts and articular chondrocytes also express IL-1Rrp2 and respond to IL-1F8, indicating a possible role in rheumatoid arthritis (RA).2

Source
Sf 21 Insect Cells
Molecular Weight
The predicted molecular weight of Recombinant Human IL-1 Rrp2 is Mr 62.8 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 80 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

d gckdifmkne ilsasqpfaf nctfppitsg evsvtwykns skipvskiiq srihqdetwi lflpmewgds gvyqcvikgr dschrihvnl tvfekhwcdt sigglpnlsd eykqilhlgk ddsltchlhf pkscvlgpik wykdcneikg erftvletrl lvsnvsaedr gnyacqailt hsgkqyevln gitvsitera gyggsvpkii ypknhsievq lgttlivdcn vtdtkdntnl rcwrvnntlv ddyydeskri regvethvsf rehnlytvni tflevkmedy glpfmchagv stayiilqlp apdfraydie grmdpkscdk thtcppcpap ellggpsvfl fppkpkdtlm isrtpevtcv vvdvshedpe vkfnwyvdgv evhnaktkpr eeqynstyrv vsvltvlhqd wlngkeykck vsnkalpapi ektiskakgq prepqvytlp psrdeltknq vsltclvkgf ypsdiavewe sngqpennyk ttppvldsdg sfflyskltv dksrwqqgnv fscsvmheal hnhytqksls lspgk

References
1. Sims JE et al. (2004) J Biol Chem. 279: 13677
2. Taylor JJ et al. (2007) Clin Exp Immunol. 147: 217
Related Products
Recombinant Rat IL-1 Rrp2 (Leinco Prod. No.: I-570)
Anti-Rat IL-1 Rrp2 (Leinco Prod. No.: I-680)
Anti-Human IL-1 Rrp2 (Leinco Prod. No.: I-714)