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Recombinant Mouse IL-1 RII

产品编号:I-569-1

产品描述:Recombinant Mouse IL-1 RII

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:订购

说明书:

Recombinant Mouse Interleukin-1 Receptor Type II (IL-1 RII)
Purified No Carrier Protein
(IL1R2, CD121b, IL1RB, MGC47725)
Prod. No.: I-569
Source Sf 21 Insect Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C 

Description
Background:

Interleukin 1 receptor type II (IL1R2), also known as CD121b (Cluster of Differentiation 121b), is a transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. It is a decoy receptor known for its ability to buffer IL-1 effects.1 IL-1RII is involved in the control of the proinflammatory state that takes place in the endometrium during the premenstrual and menstrual periods.2 IL-1RII can neutralize IL-1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis.3

Source
Sf 21 Insect Cells
Molecular Weight
The predicted molecular weight of Recombinant Mouse IL-1 RII is Mr 64.7 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 70-80 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

fttptvv htgkvsespi tsekptvhgd ncqfrgrefk selrlegepv vlrcplaphs disssshsfl twskldssql iprdeprmwv kgnilwilpa vqqdsgtyic tfrnashceq msvelkvfkn teaslphvsy lqisalsttg llvcpdlkef issnadgkiq wykgailldk gnkeflsagd ptrllisnts mddagyyrcv mtftyngqey nitrnielrv kgtttepipv iispletipa slgsrlivpc kvflgtgtss ntivwwlans tfisaayprg rvteglhhqy sendenyvev slifdpvtre dlhtdfkcva snprssqslh ttvkeiegrm dpkscdktht cppcpapell ggpsvflfpp kpkdtlmisr tpevtcvvvd vshedpevkf nwyvdgvevh naktkpreeq ynstyrvvsv ltvlhqdwln gkeykckvsn kalpapiekt iskakgqpre pqvytlppsr deltknqvsl tclvkgfyps diavewesng qpennykttp pvldsdgsff lyskltvdks rwqqgnvfsc svmhealhnh ytqkslslsp gk

References
1. Akoum A et al. (2005) Hum Rep. 20: 1177
2. Akoum A et al. (2001) Biol Rep. 65: 890
3. Liu J et al. (2008) Fertil Steril. 89: 42
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