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Recombinant Human IL-1 RAcP

产品编号:I-578-1

产品描述:Recombinant Human IL-1 RAcP

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:订购

说明书:

Recombinant Human Interleukin-1 Receptor Accessory Protein (IL-1 RAcP)
Purified No Carrier Protein
(IL1RAP, IL-1R3, C3orf13, FLJ37788)
Prod. No.: I-578
Source Sf 21 Insect Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C

Description
Background:

IL-1R accessory protein (IL-1RAcP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, necessary to link events on the plasma membrane level to downstream signaling pathways, allowing IL-1-dependent activation of transcription factors and gene expression.1 IL-1R AcP represents a novel target for blocking IL-1 function in human disease.2

Source
Sf 21 Insect Cells
Molecular Weight
The predicted molecular weight of Recombinant Human IL-1 RAcP is Mr 67 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 70-75 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

sercddwgld tmrqiqvfed eparikcplf ehflkfnyst ahsagltliw ywtrqdrdle epinfrlpen riskekdvlw frptllndtg nytcmlrntt ycskvafple vvqkdscfns pmklpvhkly ieygiqritc pnvdgyfpss vkptitwymg cykiqnfnnv ipegmnlsfl ialisnngny tcvvtypeng rtfhltrtlt vkvvgspkna vppvihspnd hvvyekepge ellipctvyf sflmdsrnev wwtidgkkpd ditidvtine sishsrtede trtqilsikk vtsedlkrsy vcharsakge vakaakvkqk vpaprytvei egrmdpkscd kthtcppcpa pellggpsvf lfppkpkdtl misrtpevtc vvvdvshedp evkfnwyvdg vevhnaktkp reeqynstyr vvsvltvlhq dwlngkeykc kvsnkalpap iektiskakg qprepqvytl ppsrdeltkn qvsltclvkg fypsdiavew esngqpenny kttppvldsd gsfflysklt vdksrwhhhh hh qqgnvfscsv mhealhnhyt qkslslspgk

References
1. Martin MU et al. (1997) J Biol Chem. 272: 7727
2. Labow MA et al. (1998) J Immunol. 161: 5614
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