产品编号:I-212-1
产品描述:Recombinant Rat IL-1β
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Rat Interleukin-1 Beta (IL-1β)
Purified No Carrier Protein
(IL1B, IL-1, IL1-Beta, IL1F2)
Prod. No.: I-212
Source E. coli
Pkg. Size: 1 mg, 10 µg, 50 µg
Storage: -20°C to -70°C
Description
Background:
Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family that is synthesized as a precursor. The IL1 beta precursor form is not biologically active. It is expressed mainly by stimulated macrophages and monocytes.1,2 IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohns disease which makes IL1 beta an important target for this disease.3
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Rat IL-1β is Mr 17 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in MES, EDTA, Dithiothreitol (DTT), sodium chloride (NaCl) and polyethylene glycol 8000 (PEG 8000).
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
mvpir qlhcrlrdeq qkclvlsdpc elkalhlngq nisqqvvfsm sfvqgetsnd kipvalglkg lnlylscvmk dgtptlqles vdpkqypkkk mekrfvfnki evktkvefes aqfpnwyist sqaehrpvfl gnsngrdivd ftmepvss
References
1. Dinarello CA et al. (1996) Blood 87: 2095
2. Yuan et al. (1993) Cell 75: 641
3. Shin Maeda et al. (2005) Science 4: 735
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