产品编号:I-577-100
产品描述:Recombinant Human IFN-γ R1
反应种属:
实验方法:
标记:
规格:100ug
供应商:Leinco
价格(RMB):5100.00
订购:
说明书:
Recombinant Human Interferon Gamma Receptor 1 (IFN-γ R1)
Purified No Carrier Protein
(CD119, IFN-γR, IFN-γRα, IFN-α R1, CDw119)
Prod. No.: I-577
Source NSO Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C
Description
Background:
IFN-γ receptor ligand-binding chain (IFNγR1) or IFN-γ R α chain, also known CDw119, is member of the class II cytokine receptor family. The IFN-γ receptor is a complex of a high affinity IFN-γ-binding chain (aka, IFN-γ R α chain) and a second accessory protein required for signal transduction known as IFN-γ R β chain. Binding of IFN-γ induces receptor dimerization and internalization. Signal transduction involves Jak1 and Jak2 protein kinases and involves STAT1 activation. The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.1,2,3
Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human IFN-γ R1 is Mr 25 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 40 and 50 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
emg tadlgpssvp tptnvtiesy nmnpivywey qimpqvpvft vevknygvkn sewidacini shhycnisdh vgdpsnslwv rvkarvgqke sayakseefa vcrdgkigpp kldirkeekq imidifhpsv fvngdeqevd ydpettcyir vynvyvrmng seiqykiltq keddcdeiqc qlaipvssln sqycvsaegv lhvwgvttek skevcitifn ssikg & g tadlgpssvp tptnvtiesy nmnpivywey qimpqvpvft vevknygvkn sewidacini shhycnisdh vgdpsnslwv rvkarvgqke sayakseefa vcrdgkigpp kldirkeekq imidifhpsv fvngdeqevd ydpettcyir vynvyvrmng seiqykiltq keddcdeiqc qlaipvssln sqycvsaegv lhvwgvttek skevcitifn ssikg
References
1. Calderon, J. et al. (1988) PNAS 85: 4837
2. A. Garcia-Sastre. et al. (2002) Int. Rev. Immunol. 21: 305
3. E. Fish. et al. (2002) J. Interferon Cytokine Res. 22: 835
Related Products
Recombinant Mouse IFN-γ R1 (Leinco Prod. No.: I-538)
Anti-Human IFN-γ R1 (Leinco Prod. No.: I-691)
Anti-Human IFN-γ R1 (Leinco Prod. No.: I-692)
Anti-Human IFN-γ R1 (Antigen Aff. Pur.) (Leinco Prod. No.: I-730)
Anti-Human IFN-γ R1-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: I-790)
Anti-Human IFN-γ R1-Fluorescein (FITC) (Leinco Prod. No.: I-824)
Anti-Human IFN-γ R1-R-phycoerythrin (R-PE) (Leinco Prod. No.: I-825)
