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Recombinant Human ICAM-3

产品编号:I-579-50

产品描述:Recombinant Human ICAM-3

反应种属:

实验方法:

标记:

规格:50ug

供应商:Leinco

价格(RMB):3300.00

订购:订购

说明书:

Recombinant Human Inter-Cellular Adhesion Molecule-3 (ICAM-3)
Purified No Carrier Protein
(CD50, CDW50, ICAM-R)
Prod. No.: I-579
Source NSO Cells
Pkg. Size: 1 mg, 50 µg, 200 µg
Storage: -20°C to -70°C

Description
Background:

Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50) is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins that bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signaling molecule.
ICAM-3 is potentially the most important ligand for LFA-1 in the initiation of the immune response because the expression of ICAM-1 on resting leukocytes is low.1 ICAM-3 is closely related to ICAM-1. 1 ICAM-3 is essentially restricted to the haemopoietic system and is reciprocal in its expression to ICAM-1, in that it is present on resting cells and its level falls as a result of cell activation.2

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human ICAM-3 is Mr 76.7 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 120 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

q efllrvepqn pvlsaggslf vncstdcpss ekialetsls kelvasgmgw aafnlsnvtg nsrilcsvyc ngsqitgssn itvyglperv elaplppwqp vgqnftlrcq veggsprtsl tvvllrweee lsrqpaveep aevtatvlas rddhgapfsc rteldmqpqg lglfvntsap rqlrtfvlpv tpprlvaprf levetswpvd ctldglfpas eaqvylalgd qmlnatvmnh gdtltatata taradqegar eivcnvtlgg errearenlt vfsflgpivn lseptahegs tvtvscmaga rvqvtldgvp aaapgqpaql qlnatesddg rsffcsatle vdgeflhrns svqlrvlygp kidratcpqh lkwkdktrhv lqcqargnpy pelrclkegs srevpvgipf fvnvthngty qcqasssrgk ytlvvvmdie agsshiegrm dpkscdktht cppcpapell ggpsvflfpp kpkdtlmisr tpevtcvvvd vshedpevkf nwyvdgvevh naktkpreeq ynstyrvvsv ltvlhqdwln gkeykckvsn kalpapiekt iskakgqpre pqvytlppsr deltknqvsl tclvkgfyps diavewesng qpennykttp pvldsdgsff lyskltvdks rwqqgnvfsc svmhealhnh ytqkslslsp gkhhhhhh

References
1. Simmons DL. et al. (1992) Nature 360: 481
2. Mason DY et al. (1994) J Clin Pathol 47: 143
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