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Recombinant Human GFRα-3

产品编号:G650-1

产品描述:Recombinant Human GFRα-3

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:订购

说明书:

Recombinant Human Glial Cell-Line Derived Neurotrophic Factor Receptor Alpha 3 (GFRα-3)
Purified No Carrier Protein
(GDNF Rα-3)
Prod. No.: G650
Source Sf 21 Insect Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C

Description
Background:

GDNF family receptor alpha 3, also known as GFRA3 is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. GFRalpha3 preferentially binds the newest member of the glial-derived neurotrophic factor family of ligands, artemin. The major site of GFRalpha3 expression is in the dorsal root ganglion.

GFRalpha3 artemin neurons are immunopositive for markers expected of nociceptors and include a subset of neurons distinct from the GDNF-responsive population.1

Source
Sf 21 Insect Cells
Molecular Weight
The predicted molecular weight of Recombinant Human GFRα-3 is Mr 67 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 67 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>90% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

gdplptesrl mnsclqarrk cqadptcsaa yhhldsctss istplpseep svpadcleaa qqlrnsslig cmchrrmrnq vacldiywtv hrarslgnye ldvspyedtv tskpwkmnls klnmlkpdsd lclkfamlct lndkcdrlrk aygeacsgph cqrhvclrql ltffekaaep haqglllcpc apndrgcger rrntiapnca lppvapncle lrrlcfsdpl crsrlvdfqt hchpmdilgt cateqsrclr aylgligtam tpnfvsnvnt svalsctcrg sgnlqeecem legffshnpc lteaiaakmr fhsqlfsqdw phptfavmah qnenpavrpq pwiegrmdpk scdkthtcpp cpapellggp svflfppkpk dtlmisrtpe vtcvvvdvsh edpevkfnwy vdgvevhnak tkpreeqyns tyrvvsvltv lhqdwlngke ykckvsnkal papiektisk akgqprepqv ytlppsrdel tknqvsltcl vkgfypsdia vewesngqpe nnykttppvl dsdgsfflys kltvdksrwq qgnvfscsvm healhnhytq kslslspgkh hhhhh (Human GFRα-3 Asp32-Trp382)

References
1. Sanicola M. et al. (2001)Eur J Neurosci 13: 2177
Related Products
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