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Recombinant Human GFRα-2

产品编号:G649-100

产品描述:Recombinant Human GFRα-2

反应种属:

实验方法:

标记:

规格:100ug

供应商:Leinco

价格(RMB):4725.00

订购:订购

说明书:

Recombinant Human Glial Cell-Line Derived Neurotrophic Factor Receptor Alpha-2 (GFRα-2)
Purified No Carrier Protein
(GDNFRB, NRTNR-Alpha, NTNRA, RETL2, TRNR2)
Prod. No.: G649
Source NSO Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C

Description
Background:

Glial cell line-derived neurotrophic factor family receptor alpha-2, also known as GFRA2, is the cognate co-receptor for the neurotrophic factor neurturin that is selectively expressed by isolectin B(4) (IB 4)-binding nociceptive sensory neurons.1 GFRA2 is required for the development of the myenteric nerve plexus and is an excellent candidate gene for Hirschsprung disease (HSCR).2 GFRalpha2 signaling is also needed for development of the parasympathetic islet innervation that is critical for vagally induced hormone secretion.3

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human GFRα-2 is Mr 74 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 100 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

spsslqgpe lhgwrppvdc vranelcaae sncssryrtl rqclagrdrn tmlankecqa alevlqespl ydcrckrgmk kelqclqiyw sihlgltege efyeaspyep vtsrlsdifr lasifsgtga dpvvsaksnh cldaakacnl ndnckklrss yisicnreis ptercnrrkc hkalrqffdr vpseytyrml fcscqdqaca errrqtilps csyedkekpn cldlrgvcrt dhlcrsrlad fhancrasyq tvtscpadny qaclgsyagm igfdmtpnyv dssptgivvs pwcscrgsgn meeecekflr dftenpclrn aiqafgngtd vnvspkgpsf qatqaprvek tpslpddlsd stslgtsvit tctsvqeqgl kannskelsm cftelttnii pgsnkvikpn sdiegrmdpk scdkthtcpp cpapellggp svflfppkpk dtlmisrtpe vtcvvvdvsh edpevkfnwy vdgvevhnak tkpreeqyns tyrvvsvltv lhqdwlngke ykckvsnkal papiektisk akgqprepqv ytlppsrdel tknqvsltcl vkgfypsdia vewesngqpe nnykttppvl dsdgsfflys kltvdksrwq qgnvfscsvm healhnhytq kslslspgkh hhhhh

References
1. Lewin GR et al. (2002) J Physiol. 545: 43
2. Mulligan Lois M et al. (2001) Human Genetics 108: 409
3. Herzig KH et al. (2005) Diabetes 54: 1324
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Anti-Mouse GFRα-2 (Antigen Aff. Pur.) (Leinco Prod. No.: G660)
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