产品编号:G638-10
产品描述:Recombinant Mouse GDNF
反应种属:
实验方法:
标记:
规格:10ug
供应商:Leinco
价格(RMB):5205.00
订购:
说明书:
Recombinant Mouse Glial-Derived Neurotrophic Factor (GDNF)
(ATF-1, ATF2, HFB1-GDNF)
Prod. No.: G638
Source E. coli
Pkg. Size: 1 mg, 10 µg
Storage: -20°C
Description
Background:
Glial cell derived neurotrophic factor, also known as GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily.1 GDNF potently promotes the survival of many types of neurons, most prominently, dopaminergic and motorneurons. GDNF regulates kidney development and spermatogenesis, and it affects alcohol consumption.2
Source
E. coli
State of Matter
Lyophilized
Purity
>98% by SDS-PAGE and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<1.0 EU/µg
Biological Activity
The biological activity of mouse GDNF is determined by the proliferation of rat C6 cells. The ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 X 106 units/mg.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
References
1. Collins F. et al. (1993)Science 260: 1130
2. Ron D et al. (2008) Proc. Natl. Acad. Sci. U.S.A. 105: 8114
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