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Recombinant Human GDF-9

产品编号:G585-20

产品描述:Recombinant Human GDF-9

反应种属:

实验方法:

标记:

规格:20ug

供应商:Leinco

价格(RMB):5205.00

订购:订购

说明书:

Recombinant Human Growth/Differentiation Factor-9 (GDF-9)
(Growth and Differentiation Factor-9)
Prod. No.: G585
Source E. Coli
Pkg. Size: 1 mg, 20 µg

Description
Background:

Growth differentiation factor 9, also known as GDF9 is a member of the transforming growth factor-beta (TGFβ) superfamily. It is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 plays an important role in the development of primary follicles in the ovary.1 It has a critical role in granulosa cell and theca cell growth, as well as in differentiation and maturation of the oocyte.2,3 GDF9 acts as a paracrine factor and affects granulosa cell physiology.7 GDF9 has been connected to differences in ovulation rate4,5 and in premature cessation of ovary function,6 therefore has a significant role in fertility.

Source
E. Coli
State of Matter
 
Purity
>98% by SDS Page and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<1.0 EU/µg
Biological Activity
Data not yet available.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence

GQETVSSELK KPLGPASFNL SEYFRQFLLP QNECELHDFR LSFSQLKWDN WIVAPHRYNP RYCKGDCPRA VGHRYGSPVH TMVQNIIYEK LDSSVPRPSC VPAKYSPLSV LTIEPDGSIA YKEYEDMIAT KCTCR

References
1. McNatty K et al. (2004) Anim Reprod Sci 82: 447
2. Hovatta O et al. (2002) J Clin Endocrinol Metab 87: 316
3. Eppig J et al. (2004) Dev Biol 276: 64
4. Juengel J. et al. Biol Reprod.
5. McNatty K et al. (2004) Biol Reprod 70: 557.
6. Carson S et al. (2007) Fertil Steril 87: 143
7. Matzuk MM. et al. (2004) J Biol Chem. 279: 32281