产品编号:G630-1
产品描述:Recombinant Human GDF-5
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Human Growth and Differentiation Factor-5 (GDF-5)
(CDMP1, LAP4, SYNS2)
Prod. No.: G630
Source E. Coli
Pkg. Size: 1 mg, 10 µg, 50 µg
Storage: -20°C
Description
Background:
Growth differentiation factor 5 (cartilage-derived morphogenetic protein-1), also known as GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. GDF5 is expressed in the developing central nervous system.1 It increases the survival of neurones that respond to a neurotransmitter called dopamine, and is a potential therapeutic molecule associated with Parkinsons disease.2
Source
E. Coli
State of Matter
Purity
>95% by SDS Page and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<0.125 EU/µg
Biological Activity
Human GDF-5 is fully biologically active when compared to standard. Induction of alkaline phosphatase acrtivity in ATDC5 cells: EC50 = 40Nm.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
APSATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR
References
1. Sullivan A et al. (2004) J Neurocytol 33: 479
2. OKeeffe G et al. (2005) J Anat 207: 219
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