产品编号:F1029-1
产品描述:Recombinant Human Flt-3 Ligand
反应种属:
实验方法:
标记:
规格:1mg
供应商:Leinco
价格(RMB):面议
订购:
说明书:
Recombinant Human Flt-3 Ligand
Purified No Carrier Protein
(Fms-Related Tyrosine Kinase 3 Ligand, Flk-2 Ligand, FL, FLT3LG, STK-1 Ligand)
Prod. No.: F1029
Source NSO Cells
Pkg. Size: 1 mg, 5 µg, 25 µg
Storage: -20°C to -70°C
Description
Background:
Fms-related tyrosine kinase 3 ligand (FLT3LG) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). In synergy with other growth factors, such as IL-7 and IL-3, Flt-3 ligand promotes long-term expansion and differentiation of human pro-B-cells.1,2 Flt3 ligand is a cytokine capable of inducing large numbers of dendritic cells that dramatically enhances the sensitivity of antigen-specific B and T cell responses to systemic injection of a soluble protein. Through a CD40-CD40 ligand-dependent mechanism Flt-3 Ligand influences the class of antibody produced and enables productive immune responses.3
Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human Flt-3 Ligand is Mr 18 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 24-28 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
tqdc sfqhspissd favkirelsd yllqdypvtv asnlqdeelc galwrlvlaq rwmerlktva gskmqgller vnteihfvtk cafqpppscl rfvqtnisrl lqetseqlva lkpwitrqnf srclelqcqp dsstlpppws prpleatapt apqpp
References
1. Mattson J et al. (1994) Nature 368: 643
2. Cleveland LS et al. (1995) Oncogene 10: 149
3. C.R. Maliszewski et al. (1998) J. Exp. Med. 188: 2075
Related Products
Recombinant Mouse Flt-3 Ligand (Leinco Prod. No.: F159)
Anti-Mouse Flt-3 Ligand (Antigen Aff. Pur.) (Leinco Prod. No.: F1062)
Anti-Mouse Flt-3 Ligand (Leinco Prod. No.: F1073)
Recombinant Human Flt-3 Ligand (Leinco Prod. No.: F114)
Anti-Human Flt-3 Ligand (Leinco Prod. No.: F1071)
Anti-Mouse Flt-3 Ligand-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: F1096)
Anti-Human Flt-3 Ligand (Leinco Prod. No.: F1076)
