产品编号:F1026-10
产品描述:Recombinant Mouse FGF-Acidic
反应种属:
实验方法:
标记:
规格:10ug
供应商:Leinco
价格(RMB):2175.00
订购:
说明书:
Recombinant Mouse FGF Acidic
(FGF-1, ECGF, HBGF-1, AFGF, ECGF-Beta, ECGFA, ECGFB, FGF-Alpha, FGFA, GLIO703)
Prod. No.: F1026
Source E. coli
Pkg. Size: 1 mg, 10 µg, 50 µg
Storage: -20°C
Description
Background:
Fibroblast growth factor 1 (acidic), also known as FGF1, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.
FGF-1 is the only member of the FGF family that binds with high affinity to all four FGF receptors.1
FGF1 plays an important role in hematopoietic stem cell homeostasis. The FGF pathway regulates primitive hematopoiesis by modulating transcription factors such as Gata1 expression level and activity.2
Source
E. coli
State of Matter
Purity
>95% by SDS Page and HPLC
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Endotoxin
<1.0 EU/µg
Biological Activity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by 3T3 cells in the presence of heparin is ≤ 0.5 ng/ml corresponding to a specific activity of ≥ 2 x 106 units/mg.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
MFNLPLGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SAGEVYIKGT ETGQYLAMDT EGLLYGSQTP NEECLFLERL EENHYNTYTS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D
References
1. Otlewski J. et al. (2009) Acta Crystallogr D Biol Crystallogr. 65: 67
2. Wang HY.et al. (2008) Zhonghua Xue Ye Xue Za Zhi 29: 535
Related Products
Anti-Human FGF-Acidic-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: F133)
Recombinant Human FGF Acidic (Leinco Prod. No.: F112)
Recombinant Human FGF-Acidic (Leinco Prod. No.: E193)
Anti-Human FGF Acidic (Leinco Prod. No.: F1065)
Anti-Human FGF-Acidic (Antigen Aff. Pur.) (Leinco Prod. No.: F106)
