产品编号:F1104-25

产品描述:Recombinant Human FGF-18

反应种属:

实验方法:

标记:

规格:25µg

供应商:Leinco

价格(RMB):5040.00

订购:

说明书:

Recombinant Human FGF-18
Purified No Carrier Protein
（zFGF5, FGFI）
Prod. No.: F1104
Source E. coli
Pkg. Size: 25 µg

Description
Background:
FGF-18 is a member of the fibroblast growth factor （FGF） family. FGF family members possess broad mitogenic ａnd cell survival activities, ａnd are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, ａnd invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse ａnd chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver ａnd small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation ａnd differentiation of midline cerebellar structures.

Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Human FGF-18 is Mr 20.1 kDa.
State of Matter
Lyophilized
Purity
>95% by SDS Page ａnd HPLC
Endotoxin
<1.0 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human FGF-18 was determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors. The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Each investigator should determine their own optimal working dilution for specific applications.
Amino Acid Sequence
AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR