产品编号:E195-1

产品描述:Recombinant Human Erythropoietin Receptor

反应种属:

实验方法:

标记:

规格:1mg

供应商:Leinco

价格(RMB):面议

订购:

说明书:

Recombinant Human Erythropoietin Receptor （ EpoR）
Purified No Carrier Protein
（MGC138358）
Prod. No.: E195
Source NSO Cells
Pkg. Size: 1 mg, 50 µg
Storage: -20°C to -70°C Detailed storage instructions below.

Description
Background:
The erythropoietin receptor is a transmembrane protein belonging to the member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin ａnd associates with ａnd activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase ａnd STAT transcription factors. EPO-R transmits signals important for both proliferation ａnd differentiation along the erythroid lineage.1 Defects in the erythropoietin receptor may produce erythroleukemia ａnd familial erythrocytosis.

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human Erythropoietin sR, Epo is Mr 25 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 32 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered ａnd lyophilized from modified Dulbecco’s phosphate buffered saline （1X PBS） pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>90% by SDS-PAGE ａnd analyzed by silver stain.
Storage ａnd Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
apppnl pdpkfeskaa llaargpeel lcfterledl vcfweeaasa gvgpgnysfs yqledepwkl crlhqaptar gavrfwcslp tadtssfvpl elrvtaasga pryhrvihin evvlldapvg lvarladesg hvvlrwlppp etpmtshiry evdvsagnga gsvqrveile grtecvlsnl rgrtrytfav rarmaepsfg gfwsawsepv slltpsdldp

Country of Origin
USA
References
1. Mathey-Prevot B et al. （1993） Proc Nathl Acad Sci USA. 90: 11351
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