产品编号:E307-25

产品描述:Recombinant Mouse Eotaxin-2 (aa 27-119)

反应种属:

实验方法:

标记:

规格:25µg

供应商:Leinco

价格(RMB):4725.00

订购:

说明书:

Recombinant Mouse Eotaxin-2
Purified No Carrier Protein
（CCL24, MPIF-2, CkB-6）
Prod. No.: E307
Source E. coli
Pkg. Size: 1 mg, 25 µg
Storage: -20°C to -70°C Detailed storage instructions below.

Description
Background:
Eotaxin-2, also known as MPIF-2 ａnd CCL24, is a member of the CC chemokine family. It interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils ａnd the release of histamine ａnd leukotriene C4 from basophils primed with IL-3 （1）. This chemokine is also strongly chemotactic for resting T lymphocytes ａnd slightly chemotatic for neutrophils （2）. Murine Eotaxin-2 appears to be produced constitutively in the jejunum ａnd spleen. Production is induced by allergen challenge ａnd IL-4 overexpression （3）. LPS ａnd IL-4 also differentially regulate the expression of Eotaxin-2 in monocytes ａnd macrophages. Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells （4）. Functionally, Eotaxin-2 is most closely related to Eotaxin/CCL11 ａnd Eotaxin-3/CCL26.

Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Mouse Eotaxin-2 is Mr 10.3 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein Mouse Eotaxin-2 was 0.2 µm filtered ａnd lyophilized from a PBS Solution.
Purity
>97% by SDS-PAGE ａnd analyzed by silver stain.
Storage ａnd Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence
vtip sscctsfisk kipenrvvsy qlangsicpk agvifitkkg hkictdpkll wvqrhiqkld akknqpskga kavrtkfavq rrrgnstev

Country of Origin
USA
References
1. Forssmann, U. et al. （1997） J. Exp. Med. 185:2171
2. Patel, V. P. et al. （1997） J. Exp. Med. 185:1163
3. Zimmerman, N. et al. （2000） J. Immunol. 1168:1911
4. Pope, S. M. et al. （2005） J. Immunol. 175:5341

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